I had had no problem with bedbugs during my adolescence year. Thanks to my mother's continual insistence in keeping the house clean, I had never been bitten by a bedbug before, and so I never truly appreciated the quote above, until I got ravaged by bedbugs (for two bloody weeks), like literally hundreds of bedbugs, during my exchange program in India. The experience was horrible enough to recall, and one that I hope no human on this planet would have to go through. I could barely sleep at all because of the seemingly never-ending itchiness.
I searched the web frantically looking for a quick solution and, to my horror, found no one-off solution. It's like you can't really exterminate them all at one go; you need to put your mattress out under the sun for a period of time—which means you may need to sleep on another mattress, spray specialized insecticides repeatedly, and seek help from professionals.